High-cell density fed-batch fermentation process for producing recombinant protein
US8632995B2 · kind B2 · utility
33Cited by
8References
79Claims
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Key dates
| Filing date | Jul 27, 2007 |
| Grant date | Jan 21, 2014 |
| Priority date | — |
| Expiry date | Apr 14, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P21/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods for producing proteins, for example, recombinant meningococcal 2086 proteins, using fed-batch fermentation with continuous input of an inducer after achieving a threshold parameter, and optionally continuous input of a carbon source, for example, a constant rate input, to improve protein yields, as well as high density protein compositions and compositions for use in the methods of the present invention, are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.