Indanyloxyphenylcyclopropanecarboxylic acids

US8633182B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Dieter Hamprecht · Verona, IT
• Sara Frattini · Castelleone, IT
• Iain Lingard · Monza, IT
• Stefan Peters · Biberach an der Riß, DE

Key dates

• Filing date: May 22, 2013
• Grant date: Jan 21, 2014
• Expiry date: May 22, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of general formula I,wherein the groups R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.