Synthesis and novel salt forms of (R)-3-((E)-pyrrolidin-3-yl)vinyl)-5-tetrahydropyran-4-yloxy)pyridine

US8633227B2 · kind B2 · utility

Assignee

• Targacept, Inc. · US

Inventors

• Srinivasa Rao Akireddy · Winston-Salem, US
• Scott R. Breining · Winston-Salem, US
• Timothy J. Cuthbertson · Winston-Salem, US
• Gary Maurice Dull · Lewisville, US
• Gregory J. Gatto · Winston-Salem, US
• John Genus · Winston-Salem, US
• Philip S. Hammond · Winston-Salem, US
• Joesph Pike Mitchener, Jr. · Winston-Salem, US
• Julio A. Munoz · Walnut Cove, US
• Pieter Albert Otten · King, US
• Daniel Yohannes · Winston-Salem, US
• Nikolai Fedorov · Winston-Salem, US

Key dates

• Filing date: Nov 30, 2009
• Grant date: Jan 21, 2014
• Expiry date: May 23, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine, its salt forms, and to processes for the commercial-scale production of these compounds in sufficient purity and quality for use in pharmaceutical compositions.