Patent · US Active

Detection of amyloid deposits using anti-amyloid antibodies

US8636981B2 · kind B2 · utility

0Cited by

10References

21Claims

0Family size

Assignee

Onclave Therapeutics Limited · IE

Inventors

Dale B. Schenk · Burlingame, US
Peter A. Seubert · South San Francisco, US
Jonathan S. Wall · Knoxville, US

Key dates

Filing date	Dec 7, 2011
Grant date	Jan 28, 2014
Priority date	—
Expiry date	Jan 12, 2032

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S530/809
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.