Anti-EpCAM antibodies

US8637017B2 · kind B2 · utility

Assignee

• Affitech Research AS · NO

Inventors

• Lavinia Diana Cicortas Gunnarsson · Oslo, NO
• Didrik Paus · Oslo, NO
• Jenny KARLSSON · Lund, SE
• Remko Albert Griep · Slemmestad, NO
• Sergej Kiprijanov · Oslo, NO

Key dates

• Filing date: Jun 9, 2010
• Grant date: Jan 28, 2014
• Expiry date: Oct 21, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are antibodies that bind to Epithelial Cell Adhesion Molecule (EpCAM) and display certain advantages over known antibodies which bind to EpCAM, for example, the antibodies of the invention show good affinity, good cross-reactivity profiles and excellent ADCC and CDCC activity. Antibodies comprising specific heavy and light chain CDRs are disclosed. The invention thus relates to these antibodies and all uses thereof, in particular in the treatment of cancer. The present invention thus provides new antibody-based compositions, methods and combined protocols for treating cancer. Advantageous immunoconjugate compositions and methods using the new anti-EpCAM antibodies are also provided.