Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof

US8637043B2 · kind B2 · utility

Assignee

• CHEMOCENTRYX, INC. · US

Inventors

• Thomas Schall · Mountain View, US
• Zhenhua Miao · San Jose, US
• Robert Berahovich · Berkeley, US
• Zheng Wei · Redwood City, US
• Maureen Howard · Los Altos Hills, US
• Brett Premack · San Francisco, US

Key dates

• Filing date: Jul 5, 2005
• Grant date: Jan 28, 2014
• Expiry date: May 19, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The inventors have discovered that a CKβ8-1 truncation variant, CKβ8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CKβ8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CKβ8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CKβ8-1 (25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1.This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.