Determination of von Willebrand Factor cleavage by ADAMTS13
US8637268B2 · kind B2 · utility
2Cited by
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24Claims
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Key dates
| Filing date | Nov 4, 2011 |
| Grant date | Jan 28, 2014 |
| Priority date | — |
| Expiry date | Nov 4, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/226
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Novel methods are described for measuring the rate of ADAMTS13-mediated cleavage of von Willebrand Factor (VWF) multimers. Through the use of the reagent, ristocetin, the method can advantageously be performed in the absence of an applied shear stress or added denaturing agent. Also described are methods for diagnosing ADAMTS13-associated disorders and methods for providing improved treatment of those disorders by evaluating the efficacy of the treatment using the methods as described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.