Oxopiperazine-azetidine amides and oxodiazepine-azetidine amides as monoacylglycerol lipase inhibitors

US8637498B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Peter J. Connolly · New Providence, US
• Mark J. Macielag · Spring House, US
• Mark McDonnell · Lansdale, US
• Bin Zhu · Spring House, US

Key dates

• Filing date: Sep 27, 2011
• Grant date: Jan 28, 2014
• Expiry date: Mar 27, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows:wherein Y, Z, and n are defined herein; andwherein Yb and Zb are as defined herein.