Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DDP-IV)

US8637546B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• David J. Madar · Gilbert, US
• Stevan W. Djuric · Libertyville, US
• Melissa J. Michmerhuizen · Gurnee, US
• Hana Kopecka · Vernon Hills, US
• Xiaofeng Li · Plano, US
• Kenton L. Longenecker · Grayslake, US
• Zhonghua Pei · South San Francisco, US
• Daisy Pireh · Lake Forest, US
• Hing L. Sham · South San Francisco, US
• Kent D. Stewart · Gurnee, US
• Bruce Szczepankiewicz · Gages Lake, US
• Paul E. Wiedeman · Libertyville, US
• Hong Yong · Libertyville, US

Key dates

• Filing date: Apr 3, 2012
• Grant date: Jan 28, 2014
• Expiry date: Apr 3, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.