Heteroaryl diamide compounds useful as MMP-13 inhibitors

US8637550B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Neil Alexander Farrow · Ridgefield, US
• Donghong Amy Gao · Hopewell Junction, US
• Alexander Heim-Riether · Ingelheim am Rhein, DE
• Sabine Schlyer · New Milford, US
• Lana Louise Smith Keenan · Poughquag, US
• Steven John Taylor · Winchester, US
• Bernd Wellenzohn · Friedrichshafen, DE
• Dieter Wiedenmayer · Biberach an der Riß, DE
• Zhaoming Xiong · Brookfield, US
• Qiang Zhang · Dalian, CN

Key dates

• Filing date: Nov 5, 2009
• Grant date: Jan 28, 2014
• Expiry date: Mar 17, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds and compositions of the formula (I) as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula (I).