Patent · US Active

Method and composition for crystallizing G protein-coupled receptors

US8637639B2 · kind B2 · utility

3Cited by

0References

26Claims

0Family size

Assignee

The Board of Trustees of the Leland Stanford Junior University · US

Inventors

Brian Kobilka · Palo Alto, US
Daniel Rosenbaum · Burlingame, US

Key dates

Filing date	Mar 30, 2012
Grant date	Jan 28, 2014
Priority date	—
Expiry date	Apr 18, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/35
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.