Patent · US Active

Process for the preparation of (2R,3S)-2-(hydroxymethyl)-5-methoxytetrahydrofuran-3-OL and acetylated derivatives thereof, free of pyranose compounds

US8637649B2 · kind B2 · utility

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18Claims

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Assignee

Johnson Matthey Public Limited Company · GB

Inventors

Xing Fu · Longbeilingcun, CN
Albrecht Zumbrunn · Territet, CH

Key dates

Filing date	Nov 23, 2011
Grant date	Jan 28, 2014
Priority date	—
Expiry date	Nov 23, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H15/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A method of preparing a ribofuranose derivative essentially free of pyranose compounds includes a step of contacting a solution of MDR containing MDRP as an impurity in a solvent including methanol and/or tetrahydrofuran with at least one alkali metal periodate under conditions sufficient to oxidize at least a portion of the MDRP. MDR containing at most 5 wt % of MDRP based on the total weight of MDR and MDRP may be produced.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.