Pyrrolyl substituted dihydroindol-2-one derivatives, preparation methods and uses thereof

US8637681B2 · kind B2 · utility

Assignee

• QILU PHARMACEUTICAL CO., LTD. · CN

Inventors

• Jingyi Wang · Chengdu, CN
• Chuanwen Fan · Shandong, CN
• Long Zhang · Hunan, CN
• Boyan Xu · Jinan, CN
• Shousheng Yan · Shandong, CN
• Zongru Guo · Jinan, CN
• Minghui Zhang · Beijing, CN
• Dong Lin · Monmouth Junction, US
• Zhantao Zhang · Shandong, CN
• Haojie Zhou · Jinan, CN

Key dates

• Filing date: Mar 31, 2011
• Grant date: Jan 28, 2014
• Expiry date: Mar 31, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided are pyrrolyl substituted dihydroindol-2-one derivatives represented by formula (I), pharmaceutically acceptable salts or solvates of said derivatives, or solvates of said salts, which are effective tyrosine kinase inhibitors. Also provided are the preparation methods of the above compounds, pharmaceutical compositions containing these compounds, and the use of these compounds in manufacturing drugs useful for the treatment or adjunctive treatment of tumors medicated by tyrosine kinases or proliferation or migration of tumor cells driven by tyrosine kinases in mammals (including human).