Macrocyclic lactone derivatives for the treatment of cancer

US8637683B2 · kind B2 · utility

Assignees

• PIRAMAL ENTERPRISES LIMITED · IN
• Oncotest GmbH · DE

Inventors

• Prabhu Dutt Mishra · Jamkhed, IN
• Shafee Mohammed Abdul · Darsi, IN
• Ram Vishwakarma · Jammu, IN
• Heinz-Herbert Fiebig · Glückstadt, DE
• Gerhard Kelter · Ehrenkirchen, DE

Key dates

• Filing date: Nov 15, 2010
• Grant date: Jan 28, 2014
• Expiry date: Nov 15, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds represented by formula (1): wherein, R1, R2, R3 and R4 are as defined in the specification, in all their stereoisomeric and tautomeric forms and mixtures thereof in all ratios, and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable polymorphs and prodrugs. The invention also relates to processes for the manufacture of compounds of formula (1) and pharmaceutical compositions containing them. The compounds and the pharmaceutical compositions of the present invention are useful for the treatment of cancer. The present invention further provides a method of treatment of cancer by administering a therapeutically effective amount of the said compound of formula (1) or its pharmaceutical composition, to a mammal in need thereof.