Method of making solid dispersions of highly crystalline therapeutic compounds
US8641948B2 · kind B2 · utility
10Cited by
7References
6Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 19, 2012 |
| Grant date | Feb 4, 2014 |
| Priority date | — |
| Expiry date | Mar 19, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for preparing solid dispersions of highly crystalline compounds. The highly crystalline or thermally labile therapeutic compounds are processed in an extruder in combination with a solubilizing agent and optionally a plasticizer. The resulting extrudate features the therapeutic compound in an amorphous state. Particularly useful as the solubilizing agents are surfactants such as poloxamers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.