Method for producing solid-lipid composite drug particles
US8642091B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 21, 2008 |
| Grant date | Feb 4, 2014 |
| Priority date | — |
| Expiry date | Feb 4, 2031 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J13/02
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method of producing solid composite lipid/drug nanoparticles that includes the steps of: (1) dissolving a lipid and a drug in a suitable organic solvent to form a solution; (2) emulsifying the solution in a liquid to form an emulsion having a discontinuous phase of micelles comprising the organic solvent, the drug and the lipid, and a continuous phase comprising the liquid; and (3) contacting the emulsion with a supercritical fluid under conditions suitable to keep the supercritical fluid in a supercritical state, whereby the supercritical fluid extracts the organic solvent from the micelles, causing them to precipitate as organic-solvent free solid composite lipid/drug nanoparticles suspended or dispersed in the liquid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.