Tumor microenvironment of metastasis (TMEM) and uses thereof in diagnosis, prognosis and treatment of tumors

US8642277B2 · kind B2 · utility

Assignees

• ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY · US
• Massachusetts Institute of Technology · US
• Cornell University · IT

Inventors

• John S. Condeelis · The Bronx, US
• Thomas Rohan · New York, US
• Frank B. Gertler · Boston, US
• Joan Jones · New York, US

Key dates

• Filing date: Jul 29, 2010
• Grant date: Feb 4, 2014
• Expiry date: Nov 14, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/56
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Disclosed are methods for determining the risk of tumor cells undergoing metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, and for determining a course of treatment for a localized tumor comprising detecting the presence of an endothelial cell, a macrophage, and an invasive tumor cell in direct apposition in a tumor sample from a subject.