Methods for identifying agents that alter NAD-dependent deacetylation activity of a SIR2 protein
US8642284B1 · kind B1 · utility
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34References
18Claims
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Key dates
| Filing date | Dec 13, 2000 |
| Grant date | Feb 4, 2014 |
| Priority date | — |
| Expiry date | Jan 19, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods of identifying agents which alter the NAD-dependent deacetylation activity of a Sir2 protein or a fragment of a Sir2 protein are disclosed. The acetylated protein can be a nuclear protein, such as a histone protein, or a cytoplasmic protein. The Sir2 protein employed in the methods can include at least a core domain of a Sir2 protein, such as a human Sir2 protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.