Encoded self-assembling chemical libraries (ESACHEL)
US8642514B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 8, 2009 |
| Grant date | Feb 4, 2014 |
| Priority date | — |
| Expiry date | Feb 22, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule, and an oligonucleotide (b) or functional analogue thereof. The oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capable of performing a combination reaction with at least one self-assembly sequence (b1′) of a complementary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q). In a some embodiments, the chemical compound comprises a coding sequence (b1) coding for the identification of the chemical moiety (p) and further comprises at least one self-assembly moiety (m) capable of performing a combination reaction with at least one self-assembly moiety (m′) of a similar chemical compound comprising a chemical moiety (q). The invention also provides corresponding libraries of chemical compounds as well as methods of biopanning for target molecules and of identifying such targets.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.