Excipients for protein stabilization
US8642532B2 · kind B2 · utility
1Cited by
8References
6Claims
0Family size
Inventor
Key dates
| Filing date | Nov 17, 2008 |
| Grant date | Feb 4, 2014 |
| Priority date | — |
| Expiry date | Apr 9, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0073
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is a method of using a class of excipients for protein formulation to reduce and/or eliminate protein aggregation in solutions or solids. This class of compounds contains carbonyl group(s) to form Schiff base(s) with amino groups of proteins and also contains moieties to keep protein molecules spatially separated. This method has never been disclosed anywhere in the literature.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.