Formulation and use thereof

US8642627B2 · kind B2 · utility

Assignee

• McNeil AB · US

Inventors

• Mark P. Warchol · Kalamazoo, US
• Folke Moren · Malmö, SE
• Kristina Thyresson · Lund, SE
• Elisabeth Sthengel · Helsingborg, SE
• Sven-Borje Andersson

Key dates

• Filing date: Jun 18, 2010
• Grant date: Feb 4, 2014
• Expiry date: Jul 9, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are liquid pharmaceutical formulations comprising nicotine in any form for administration essentially to the lungs being acidified and/or alkalized by buffering and/or pH regulation providing for a tmax of nicotine in arterial blood of a subject within a short period of time after administration. The administration is preferably accomplished by spraying an aerosol into the oral cavity for further distribution essentially into the lungs. Methods for manufacturing the formulation is also disclosed, as are uses of the formulation in therapy, such as therapy for treating addiction to tobacco.