Patent · US Active

Method for predicting organ toxicity and a system thereof

US8645075B2 · kind B2 · utility

0Cited by

1References

8Claims

0Family size

Assignee

STRAND LIFE SCIENCES PRIVATE LIMITED · IN

Inventors

Kalyanasundaram Subramanian · Bengaluru, IN
Sowmya Raghavan · Bengaluru, IN
Anupama Rajan Bhat · Bhavnagar, IN
Sonali Das · Vijayraghavgarh, IN
Jyoti Bajpai Dikshit · Bengaluru, IN
Rajeev Kumar · Purnia, IN
Narasimha Mandyam Krishnakumar · Nagamangala, IN
Nalini Rajeshwara · Nagamangala, IN
Rajesh Radhakrishnan · Maple Grove, US
Srivatsan Raghunathan · Pollachi, IN

Key dates

Filing date	Dec 9, 2009
Grant date	Feb 4, 2014
Priority date	—
Expiry date	Sep 24, 2030

Classification

Technology area (CPC G)Physics
CPC primaryG16B25/00
WIPO fieldComputer technology
WIPO sectorElectrical engineering

Abstract

The attached disclosure provides a systems approach based on mathematical modelling of the kinetics of essential biochemical pathways involved in organ homeostasis. When this in silico model is coupled with in-vitro and/or in-vivo measurements to quantify drug-induced perturbations, a powerful platform that allows accurate and mechanistic-level prediction of drug-induced organ injury can be generated. The method described in this disclosure demonstrates that several physiological situations can also be accurately modelled in addition to the effect of perturbations induced by drugs. It can also be used along with high-throughput “omics” data to generate testable hypotheses leading to informed decision-making in drug development.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.