Microbial reductive dehalogenation of vinyl chloride

US8647824B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Alfred M. Spormann · Stanford, US
• Jochen A. Müller · Baltimore, US
• Bettina M. Rosner · San Diego, US
• Gregory Von Abendroth · White Plains, US
• Galit Meshulam-Simon · Los Altos, US
• Perry L. McCarty · Stanford, US

Key dates

• Filing date: Nov 11, 2011
• Grant date: Feb 11, 2014
• Expiry date: Nov 11, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/0004
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of assessing the capability of endogenous organisms at an environmental site to metabolize vinyl chloride; and a method of using the strains of the invention for bioremediation.