Method for determining amino-terminal proANP in patients having a cardiac disease or being suspected of developing or having a cardiac disease

US8647830B2 · kind B2 · utility

Assignee

• B.R.A.H.M.S GMBH · DE

Inventors

• Andreas Bergmann · Berlin, DE
• Jana Papassotiriou · Berlin, DE
• Joachim Struck · Berlin, DE
• Nils Morgenthaler · Berlin, DE
• Stefan Anker · Berlin, DE

Key dates

• Filing date: May 6, 2008
• Grant date: Feb 11, 2014
• Expiry date: Jun 28, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/324
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to an in vitro method for medical diagnosis, prognosis and therapy follow-up for patients having a cardiac disease or being suspected of developing or having a cardiac disease comprising the steps of: providing a sample of a patient having a cardiac disease or being suspected of developing or having a cardiac disease, determining amino-terminal proANp or partial peptides thereof having from 12 to 98 amino acids in said sample using at least one antibody that binds specifically to a partial sequence of amino-terminal proANP, attributing the determined amino-terminal proANP level or the level of partial peptides thereof to a clinical picture wherein the attribution is carried out independent of the BMI of the patient. The present invention further concerns a rapid test assay and a kit for conducting the method of the present invention and the use of antibodies suitable for the method and assays according to the present invention.