Peptide probe for rapid and specific detection of β-amyloid aggregation
US8647879B2 · kind B2 · utility
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24Claims
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Key dates
| Filing date | Aug 13, 2010 |
| Grant date | Feb 11, 2014 |
| Priority date | — |
| Expiry date | Aug 13, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/25625
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A peptide probe that generates fluorescence signals rapidly upon recognition of various Aβ aggregates without significant perturbation of samples. The present peptide probes display an increase in fluorescence signals upon coincubation with Aβ oligomers, but neither monomeric/dimeric species nor fibrils. The detection can occur within an hour or two without any additional sample preparation and incubation steps.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.