Heterocycloalkyl-containing thienopyrimidines for pharmaceutical compositions

US8648068B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Thorsten Lehmann-Lintz · Ochsenhausen, DE
• Joerg Kley · Mittelbiberach, DE
• Norbert Redemann · Biberach, DE
• Achim Sauer · Ravensburg, DE
• Leo Thomas · Biberach, DE
• Dieter Wiedenmayer · Biberach an der Riß, DE
• Matthias Austen · Oebisfelde, DE
• John C. Danilewicz · Canterbury, GB
• Martin Schneider · Remchingen, DE
• Kay Schreiter · Göttingen, DE
• Phillip Black · Saffron Walden, GB
• Wesley Blackaby · Cambridge, GB
• Ian Linney · London, GB

Key dates

• Filing date: Feb 25, 2011
• Grant date: Feb 11, 2014
• Expiry date: Nov 15, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel pharmaceutical compositions comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.