Substituted octahydropyrrolo[1,2-a]pyrazine sulfonamides as calcium channel blockers

US8648074B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Tao Li · San Diego, US
• Sachin V. Patel · Round Lake, US
• Richard J. Perner · Gurnee, US
• John T. Randolph · Libertyville, US
• Michael R. Schrimpf · Grayslake, US
• Kevin R. Woller · Antioch, US
• Zhiren Xia · Gurnee, US
• Qingwei Zhang · Shanghai, CN

Key dates

• Filing date: Sep 26, 2012
• Grant date: Feb 11, 2014
• Expiry date: Sep 26, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P29/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to: (a) compounds of Formula (I):and salts thereof, wherein Z′, Z″, L2, G2, R1, and R2 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel blockers.