Patent · US Active

Activated solid support and method

US8648146B2 · kind B2 · utility

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0References

17Claims

0Family size

Assignee

GE Healthcare Bio-Science AB · US

Inventors

Gunnar Glad · Uppsala, SE
Jean-Luc Maloisel · Uppsala, SE
Nicolas Thevenin · Uppsala, SE

Key dates

Filing date	Jun 6, 2012
Grant date	Feb 11, 2014
Priority date	—
Expiry date	Jun 6, 2032

Classification

Technology area (CPC B)Performing Operations; Transporting
CPC primaryB01J2220/58
WIPO fieldChemical engineering
WIPO sectorChemistry

Abstract

Disclosed is a method for activating a solid support material with epoxy groups and for immobilizing ligands thereon, utilizing phase transfer catalytic conditions. The method permits the introduction of epoxy groups and specific nucleophilic ligands on the support material with a high level of substitution. Furthermore, the invention provides a general method for immobilizing a ligand for use in a wide variety of chromatographic separation procedures such as ion exchange chromatography, hydrophobic interaction chromatography (HIC), reverse phase chromatography (RPC), or affinity chromatography.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.