Methods and compositions of DNA ligands for arthropod-borne pathogen detection and prophylaxis or therapy
US8648181B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 18, 2011 |
| Grant date | Feb 11, 2014 |
| Priority date | — |
| Expiry date | Aug 18, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Specific DNA ligand sequences for binding various arthropod-borne pathogens including arboviruses, rickettsia and parasites are described. Each of these sequences or their linear, two-and three-dimesional linked sequences can function in varying assay and sensor formats with varying degrees of success. Linkage of the whole or partial DNA sequences (putative binding sites) can be used to enhance specificity and affinity towards complex targets, thereby improving assay selectivity and sensitivity in many instances. In addition, the DNA sequences may bind and neutralize or prevent infection from arthropod-borne viruses, rickettsia and Leishmania or other parasites.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.