Patent · US Active

Processes suitable for the preparation of salmeterol

US8648214B2 · kind B2 · utility

1Cited by

7References

52Claims

0Family size

Assignee

Generics [UK] Limited · GB

Inventors

Vinayak Govind Gore · Panvel, IN
Avinash C. Gaikwad · Jamkhed, IN
Maheshkumar Gadakar · Jamkhed, IN
Vinay Kumar Shukla · Jamkhed, IN

Key dates

Filing date	Apr 16, 2008
Grant date	Feb 11, 2014
Priority date	—
Expiry date	Mar 25, 2029

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to processes for the preparation of 4-hydroxy-α′-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthoate (salmeterol xinafoate) (12a), the preparation of 4-hydroxy-α′-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (salmeterol) (11), the preparation of protected N-[6-(4-phenylbutoxy)hexyl]amine intermediates (7), and the preparation of 6-substituted (4-phenylbutoxy)hexane intermediates (5), shown below, wherein X is a leaving group and Pg is a protecting group.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.