Method of performing wavelength modulated differential laser photothermal radiometry with high sensitivity
US8649835B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Nov 17, 2010 |
| Grant date | Feb 11, 2014 |
| Priority date | — |
| Expiry date | Mar 12, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01T1/1603
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Methods are provided for the detection of an analyte in a sample using wavelength modulated differential photothermal radiometry with enhanced sensitivity. A wavelength modulated differential photothermal radiometry system, comprising two optical modulated beams, where each beam experiences different absorption by the analyte, is calibrated by controlling the relative phase difference between the modulated beams so that individual photothermal signals corresponding to each modulated beam are 180° out of phase, corresponding to peak sensitivity to analyte concentration. The system may be further calibrated by varying the relative intensities of the two modulated beams and measuring standards containing known analyte concentration in order to determine an optimal relative intensity for a given concentration range of interest.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.