Dek protein compositions and methods of using the same

US8652467B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• David Markovitz · Ann Arbor, US
• Nirit Mor-Vaknin · Ann Arbor, US
• Michael Khodadoust · Ann Arbor, US
• Barbara S. Adams · Ann Arbor, US

Key dates

• Filing date: Oct 16, 2006
• Grant date: Feb 18, 2014
• Expiry date: Feb 19, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to DEK protein compositions (e.g., antibodies, small molecule inhibitors, siRNAs) and methods of using the same. In particular, the present invention provides compositions and methods for treating autoimmune disease (e.g., juvenile rheumatoid arthritis, lupus, etc.) and for inhibiting inflammation (e.g., associated with autoimmune disease) and cellular chemotaxis (e.g., of neutrophils, NK cells and T cells). The present invention further provides a diagnostic marker (e.g., DEK antigen) for autoimmune disease.