Patent · US Active

Method of screening a modulator of endothelial NO synthase comprising the use of heme binding protein 1

US8652785B2 · kind B2 · utility

0Cited by

1References

10Claims

0Family size

Assignee

Sanofi · FR

Inventors

Alexandra KROG · Bodenheim, DE
Jochen Kruip · Frankfurt am Main, DE
Paulus Wohlfart · Frankfurt am Main, DE
Johann Gassenhuber · Wiesbaden, DE
Kathrin Heermeier · Hochheim, DE
Hartmut Strobel · Liederbach, DE
Natalie Karst · Paris, FR
Alexandra Ferrier · Paris, FR
Christian Viskov · Paris, FR

Key dates

Filing date	Nov 27, 2009
Grant date	Feb 18, 2014
Priority date	—
Expiry date	Nov 27, 2029

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P9/10
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention relates to a method of screening for a modulator of endothelial NO synthase (eNOS) expression, a method of diagnosing a cardiovascular disease in a subject, the use of HEBP-1 for the identification of a medicament for preventing and/or treating a disease involving eNOS dysfunction, particularly a cardiovascular disease, the use of HEBP-1 for the detection of a component of eNOS signal transduction, and the use of HEBP1 for the regulation of eNOS promoter activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.