Method of classifying human subjects having adolescent idiopathic scoliosis (AIS) and method for screening for a compound useful in the treatment of AIS and related syndromes causing spinal deformities
US8652791B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Dec 24, 2012 |
| Grant date | Feb 18, 2014 |
| Priority date | — |
| Expiry date | Dec 24, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of classifying a human subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting an impairment in melatonin-signaling pathway in the sample in the presence and in the absence of a known melatonin-signaling pathway agonist, whereby the results of the detecting step enables the classification of the subject having AIS in one AIS subgroup; and a method of screening for a compound useful in the treatment of a disease characterized by a dysfunctional melatonin-signaling pathway, said method comprising the steps of contacting a candidate compound with at least one cell expressing at least one melatonin-signaling pathway impairment, wherein the candidate compound is selected if said melatonin-signaling pathway impairment is reduced in the presence of the candidate compound as compared to that in the absence thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.