Methods of NAD-dependent deacetylation of a lysine residue in a protein
US8652797B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Sep 12, 2008 |
| Grant date | Feb 18, 2014 |
| Priority date | — |
| Expiry date | Aug 5, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of NAD-dependent of at least one lysine residue in an acetylated protein are disclosed. The methods include combining the acetylated protein with an isolated Sir2 protein or fragment that includes a core domain of the Sir2 protein. The Sir2 protein or fragment of the Sir2 protein can include a human Sir2 protein or a fragment of a human Sir2 protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.