Method and means for producing high titer, safe, recombinant lentivirus vectors
US8652837B2 · kind B2 · utility
0Cited by
24References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 20, 2007 |
| Grant date | Feb 18, 2014 |
| Priority date | — |
| Expiry date | May 4, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/003
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.