Polymeric benzyl carbonate-derivatives

US8653131B2 · kind B2 · utility

Assignees

• Baxter Healthcare SA · CH
• Baxter International Inc. · US

Inventors

• Guohan Yang · Mansfield, US
• Ton That Hai · Round Lake, US
• Bennett Melnick · Chicago, US
• Paul Sanders · Greendale, US
• Cong Jiang · Gurnee, US
• Catherine Quinn · Mundelein, US
• Jie Li · Zofingen, CH
• Arounaguiry Ambroise · Cary, US
• Larry R. Brown · Newton, US

Key dates

• Filing date: Aug 21, 2009
• Grant date: Feb 18, 2014
• Expiry date: May 24, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.