Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein

US8653282B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Rogelio P. Frutos · Sandy Hook, US
• Dhileepkumar Krishnamurthy · Westborough, US
• Jason Alan Mulder · New Milford, US
• Sonia Rodriguez · Avon, US
• Chris Hugh Senanayake · Brookfield, US
• Thomas G. Tampone · Southbury, US

Key dates

• Filing date: Oct 15, 2008
• Grant date: Feb 18, 2014
• Expiry date: Dec 22, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof, (I) wherein X is SO or SO2, preferably SO, and wherein RA, R1, R2, R3, R4 and R5 have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said compounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.