Fibroblast growth patterns for diagnosis of Alzheimer's disease
US8658134B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 2, 2010 |
| Grant date | Feb 25, 2014 |
| Priority date | — |
| Expiry date | Oct 2, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2821
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods of diagnosing Alzheimer's disease are provided. At least five methods of diagnostic measurements are presented: Method 1: Integrated score; Method 2: Average aggregate area per number of aggregates; Method 3: Cell migration analysis; Method 4; Fractal analysis; Method 5: Lacunarity Analysis. In certain embodiments, a sample of a subject's skin provides a network of fibroblasts that is imaged and a fractal dimension of the image is calculated. The fractal dimension can be compared to an aged-matched control (non-Alzheimer's) database to determine if the subject has Alzheimer's disease. The network of fibroblasts may be cultured in a matrix, for example in a protein mixture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.