Polymer derived from linear polyethylenimine for gene transfer
US8658150B2 · kind B2 · utility
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10References
18Claims
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Key dates
| Filing date | Mar 4, 2009 |
| Grant date | Feb 25, 2014 |
| Priority date | — |
| Expiry date | Apr 3, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08L79/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a static copolymer of linear polyethylenimine that comprises two monomer units of the following formulas I and II, in which R1 is a hydrogen atom or a C1-C6 alkyl radical, R2 is a hydrogen atom, a C1-C6 alkyl, aryl or aralkyl group, wherein the alkyl group is a C1-C6 one, n is a number between 1 and 99% of the total monomers, m is a number between 1 and 99% of the total monomers, and advantageously m+n=100%. The invention also relates to complexes of this copolymer with a nucleic acid, and to the use thereof in in vivo, in vitro or ex vivo gene transfection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.