Compositions and methods relating to non-human animals modified to promote production of selected gametes
US8658155B2 · kind B2 · utility
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1Claims
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Key dates
| Filing date | Dec 27, 2011 |
| Grant date | Feb 25, 2014 |
| Priority date | — |
| Expiry date | Dec 27, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/8775
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods and compositions for producing selected non-human mammalian germ cells and gametes and for making non-human animals using the produced germ cells and gametes are provided by the present invention. Methods of generating a non-human embryo and/or animal derived from donor stem cells, methods of generating chimeric non-human animals having substantially all gametes and/or germ cells derived from the donor stem cells, methods of producing a non-human host embryo lacking functional endogenous germ cells and non-human host embryos incapable of developing endogenous gametes of the present invention are described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.