Method to induce and expand therapeutic alloantigen-specific human regulatory T cells in large-scale
US8658159B2 · kind B2 · utility
2Cited by
0References
6Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Apr 30, 2009 |
| Grant date | Feb 25, 2014 |
| Priority date | — |
| Expiry date | Jan 27, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2502/11
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for inducing, expanding, and/or generating alloantigen-specific regulatory T cells. Alloantigen-specific regulatory T cells can be induced, expanded, and/or generated from naive CD4+CD25− T cells by using CD40-activated B cells. The regulatory T cells can be human T cells. In one embodiment, the alloantigen-specific human regulatory T cells can be CD4highCD25+Foxp3+ regulatory T cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.