Compositions and methods for homoconjugates of antibodies which induce growth arrest of apoptosis of tumor cells
US8658168B2 · kind B2 · utility
7Cited by
5References
9Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 8, 2002 |
| Grant date | Feb 25, 2014 |
| Priority date | — |
| Expiry date | Dec 21, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/77
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The homoconjugates exert anti-growth activity by signaling G0/G1 arrest or apoptosis, depending upon which cell surface molecule they bind. This activity is specific and does not require an Fc portion. These conjugates are potent, anti-tumor agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.