Polyconjugates for in vivo delivery of polynucleotides
US8658211B2 · kind B2 · utility
69Cited by
2References
23Claims
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Assignee
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Key dates
| Filing date | Feb 8, 2012 |
| Grant date | Feb 25, 2014 |
| Priority date | — |
| Expiry date | Mar 7, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible or labile linkages connecting component parts provides for physiologically responsive activity modulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.