Anti-(influenza a virus subtype H5 hemagglutinin) monoclonal antibody
US8658354B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 26, 2009 |
| Grant date | Feb 25, 2014 |
| Priority date | — |
| Expiry date | Aug 6, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/11
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A virus, and a kit therefor, and a novel anti-H5 subtype influenza A virus monoclonal antibody which can be used for the immunoassay are disclosed. The antibody or an antigen-binding fragment thereof of the present invention undergoes antigen-antibody reaction with hemagglutinin of H5 subtype influenza A virus, and the corresponding epitope of the antibody or an antigen-binding fragment thereof is located in a region other than the receptor subdomain (excluding C-terminal region thereof consisting of 11 amino acids), which antibody or an antigen-binding fragment thereof does not have neutralizing activity against the influenza A virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.