Molecules and methods for demethylation of methylated nucleic acid sequences
US8658393B2 · kind B2 · utility
5Cited by
2References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 5, 2012 |
| Grant date | Feb 25, 2014 |
| Priority date | — |
| Expiry date | Oct 5, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Demethylation of a methylated DNA sequence in a eukaryotic cell is described, utilizing a molecule that includes at least a first domain that exhibits a cytidine deaminase activity and at least a second domain that confers either a specific or non-specific DNA binding activity. The molecules of the invention are useful in somatic cell nuclear transfer and also in cancer therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.