Patent · US Active

Biocatalysts for manufacturing duloxetine alcohol

US8658400B2 · kind B2 · utility

0Cited by

2References

25Claims

0Family size

Assignee

BASF SE

Inventors

Nina Schneider · Edingen-Neckarhausen, DE
Hans Wolfgang Höffken · Ludwigshafen, DE

Key dates

Filing date	Dec 16, 2009
Grant date	Feb 25, 2014
Priority date	—
Expiry date	Dec 17, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P7/22
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use of said mutants; and particularly to a method for manufacturing duloxetine alcohol or duloxetine, comprising a synthesis step catalyzed biocatalytic by said mutants.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.