Methods for preventing or reducing neurotoxicity associated with administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs
US8658618B2 · kind B2 · utility
0Cited by
4References
40Claims
0Family size
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Inventor
Key dates
| Filing date | Oct 14, 2010 |
| Grant date | Feb 25, 2014 |
| Priority date | — |
| Expiry date | Dec 9, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme in both nervous and non-nervous tissues within the patient and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU generated from a prodrug is in substantial excess of DPD inhibitor in the patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.