Crystalline CDC7 inhibitor salts
US8658662B2 · kind B2 · utility
1Cited by
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6Claims
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Key dates
| Filing date | Nov 5, 2010 |
| Grant date | Feb 25, 2014 |
| Priority date | — |
| Expiry date | Nov 5, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel crystalline salts of a CDC7 or CDC7/CDKs inhibitor, to a novel crystal form of the corresponding free base, to a process for their preparation, to hydrates, solvates and polymorphs of such new salt forms, to their use in therapy and to pharmaceutical compositions containing them. Such crystal salts are selected from L-asparate, hemifumarate, hydrochloride, maleate, mesylate, sulfate, L-tartrate or phosphate salts of 5-(2-amino-pyrimidin-4-yl)-2-(2,4-dichloro-phenyl)-1H-pyrrole-3-carboxylic acid amide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.