Synthesis of stable elastomeric negative acoustic contrast particles
US8658734B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 11, 2010 |
| Grant date | Feb 25, 2014 |
| Priority date | — |
| Expiry date | Oct 9, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/54313
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays. Potential applications of these elastomeric negative acoustic contrast particles include sensitive bioassays based on acoustic flow cytometry and other types of techniques that utilize acoustic fields, including ultrasound imaging and ultrasound triggered drug delivery.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.